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March 07, 2017

TUSTIN, CA. - March 7, 2017 MicroVention, Inc., a wholly owned subsidiary of Terumo Corporation, announced today that the multicenter GREAT study achieved its primary and secondary endpoints. The primary endpoint of the study was met with statistical significance showing lower adverse composite outcomes in the patients treated with 2nd generation HydroCoil® Embolic System coils when compared to bare platinum coils.

The GREAT study (German Randomized Endovascular Aneurysm Trial) was a prospective, randomized, controlled trial that enrolled 513 patients at 22 hospitals in France and Germany. The adverse event primary endpoint was a composite of major aneurysm recurrence at 18 months, retreatment at 18 months, morbidity preventing angiographic follow-up, and all deaths regardless of cause. Investigators treated medium-sized (4-12mm) ruptured and unruptured intracranial aneurysms using at least 50% hydrogel coils by length or all bare platinum coils. Principal Investigator for the trial, Professor Christian Taschner from the University of Freiburg, Germany presented the study data at the 2017 International Stroke Conference in Houston, Texas, USA on February 23rd, 2017.

The GREAT trial results showed significant benefits of hydrogel technology, noted Professor Taschner. "Aneurysm treatment technology is evolving quickly. It is important to understand the safety and efficacy of new devices through sound scientific methods. I was intrigued by the opportunity to test whether MicroVention's unique hydrogel technology can improve patient outcomes in a wide-range of aneurysms," commented Professor Taschner. "We are pleased that this independent study showed that hydrogel technology reduces a composite of adverse events, retreatments, morbidity and mortality compared to traditional bare platinum coils."

"The results of the GREAT randomized trial demonstrate the efficacy of aneurysm treatment using our hydrogel coils and are aligned with the results of other clinical studies on this technology," added Richard E. Cappetta, President and CEO of MicroVention, Inc.

MicroVention's 2nd generation HydroCoil Embolic System features a non-bioactive, inert hydrogel core that absorbs water from the blood and surrounding tissue, to create a stable, mechanical platform for natural tissue proliferation and long-term aneurysm occlusion. HydroFrame®, HydroFill® and HydroSoft® Embolic Coils can be used exclusively or in conjunction with traditional bare platinum coils to safely and effectively embolize a wide range of aneurysms and neurovascular lesions.

About MicroVention, Inc.

MicroVention, Inc. is a U.S. subsidiary of Terumo Corporation with its corporate headquarters in Tustin, California, and manufacturing and administrative facilities in Tustin and Aliso Viejo, California, and San José, Costa Rica. MicroVention is a developer, manufacturer and marketer of innovative neuroendovascular technologies for the treatment of vascular diseases in small vessels. MicroVention products are sold throughout the world in more than 70 countries. For more information,visit

http://www.microvention.com.

About Terumo

Terumo (TSE: 4543) is a global leader in medical technology and has been committed to “Contributing to Society through Healthcare” for 100 years. Based in Tokyo and operating globally, Terumo employs more than 28,000 associates worldwide to provide innovative medical solutions in more than 160 countries and regions. The company started as a Japanese thermometer manufacturer, and has been supporting healthcare ever since. Now, its extensive business portfolio ranges from vascular intervention and cardio-surgical solutions, blood transfusion and cell therapy technology, to medical products essential for daily clinical practice such as transfusion systems, diabetes care, and peritoneal dialysis treatments. Terumo will further strive to be of value to patients, medical professionals, and society at large.

Among the information that Terumo discloses, the forward-looking statements including financial projections are based upon our assumptions using information available to us at the time and are not intended to be guarantees of future events or performance. Accordingly, it should be noted that actual results may differ from those forecasts or projections due to various factors. Factors affecting to actual results include, but are not limited to, changes in economic conditions surrounding Terumo, fluctuations of foreign exchange rates, and state of competition.

 

Information about products (including products currently in development) included in this material is not intended to constitute an advertisement or medical advice.