Terumo Blood and Cell Technologies Joins Cell and Gene Therapy Catapult Process Analytical Technology (PAT) Consortium The company will contribute its full range of automation technology and scientific expertise to help accelerate technology development and potentially lower cost in cell and gene therapy manufacturing.

June 8, 2021

LAKEWOOD, COLO., U.S.A. - June 8, 2021 - Terumo Blood and Cell Technologies, the medical technology company specializing in a portfolio of technology, software and services for blood component collection, therapeutic apheresis and cellular technologies, today announces that it will join a consortium aiming to increase process efficiency, consistency and quality while potentially lowering overall costs of cell and gene therapies. The Process Analytical Technology (PAT) Consortium aims to increase efficiencies and lower overall costs by assessing applications and combinations of multiple technologies for process analytics within cell and gene therapy (CGT) manufacturing. These strategies support the Company's drive to increase patient access to therapies.

Terumo Blood and Cell Technologies, by joining the PAT Consortium, will become part of the largest global consortium in the cell and gene therapy sector both in its ambitions and objectives and in its expertise and number of participating organisations. The consortium is led by the Cell and Gene Therapy Catapult, an independent center of excellence established to advance the growth of the UK cell and gene therapy industry. The PAT Consortium initially comprises 23 organizations including pharmaceutical companies; therapeutic developers; technology providers of sensors, manufacturing system and analytical tools; raw material providers; and charitable organizations. The collaboration will be funded by the Cell and Gene Therapy Catapult with selective additional support, either financial or with materials. from the consortium members.

The Cell and Gene Therapy Catapult selected Terumo Blood and Cell Technologies because of previous collaborations evaluating the company's automated cell expansion platform, known as the Quantum® Cell Expansion System, in several applications that included culture of induced pluripotent stem cells (iPSC) and the manufacture of viral vectors. The Cell and Gene Therapy Catapult are currently working in collaboration with Terumo Blood and Cell Technologies to develop a suspension cell expansion protocol relevant to the PAT Consortium project.

In addition to using the Quantum system, the consortium will access the company's full range of scientific expertise concerning automation and general use of bioreactors. Dalip Sethi, Ph.D., Director of Scientific Affairs, Terumo Blood and Cell Technologies, will sit on the PAT Consortium steering committee.

"The cell and gene therapy sector has seen increasing clinical, therapeutic and commercial successes. For this to continue, we need increased collaboration between a range of sector organizations to overcome current industry challenges, including process development. By joining the PAT Consortium, we will contribute, share and acquire a broad range of expertise that will have a direct impact on the delivery of therapies to a broader number of patients." -Delara Motlagh, General Manager, Cell Therapy Technologies, Terumo Blood and Cell Technologies

By collaborating with fellow consortium members, Terumo Blood and Cell Technologies will gain additional knowledge and data concerning the use of bioreactors in cell and gene therapy process development and their application within the wider development and manufacturing processes. This knowledge will be vital to future development of its technologies, software and services for cell and gene therapies.

Consortium Focus

The consortium identified PAT development as critical to success of the cell and gene therapy industry. By developing improved PAT, the consortium aims to increase process efficiency and reduce batch failures through the creation of predictive analytics and adaptive processing. This is a key element in accelerating the approval and commercialization of medicines across the cell and gene therapy sector. In combination with adaptive manufacturing, it will allow more detailed monitoring and control of the manufacturing process. The consortium will assess multiple process analytical technologies, both newly developed for CGT and newly applied from other industries. These technologies will also be evaluated in specific manufacturing settings, in or alongside closed system processing and with specific CGT materials and equipment.

About Terumo Blood and Cell Technologies

Terumo Blood and Cell Technologies is a medical technology company. Our products, software and services enable customers to collect and prepare blood and cells to help treat challenging diseases and conditions. Our employees around the world believe in the potential of blood and cells to do even more for patients than they do today.

Terumo Blood and Cell Technologies' customers include blood centers, hospitals, therapeutic apheresis clinics, cell collection and processing organizations, researchers and private medical practices. Our customers are based in over 130 countries across the globe. We have 750+ granted patents, with more than 150 additionally pending.

We have global headquarters in Lakewood, Colorado, U.S. along with five regional headquarters, six manufacturing sites and six innovation and development centers across the globe. Terumo Blood and Cell Technologies is a subsidiary of Terumo Corporation (TSE: 4543), a global leader in medical technology.

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About Terumo

Terumo (TSE: 4543) is a global leader in medical technology and has been committed to "Contributing to Society through Healthcare" for 100 years. Based in Tokyo and operating globally, Terumo employs more than 25,000 associates worldwide to provide innovative medical solutions in more than 160 countries and regions. The company started as a Japanese thermometer manufacturer, and has been supporting healthcare ever since. Now, its extensive business portfolio ranges from vascular intervention and cardio-surgical solutions, blood transfusion and cell therapy technology, to medical products essential for daily clinical practice such as transfusion systems, diabetes care, and peritoneal dialysis treatments. Terumo will further strive to be of value to patients, medical professionals, and society at large.

About Terumo

Terumo (TSE: 4543) is a global leader in medical technology and has been committed to "Contributing to Society through Healthcare" for 100 years. Based in Tokyo and operating globally, Terumo employs more than 25,000 associates worldwide to provide innovative medical solutions in more than 160 countries and regions. The company started as a Japanese thermometer manufacturer, and has been supporting healthcare ever since. Now, its extensive business portfolio ranges from vascular intervention and cardio-surgical solutions, blood transfusion and cell therapy technology, to medical products essential for daily clinical practice such as transfusion systems, diabetes care, and peritoneal dialysis treatments. Terumo will further strive to be of value to patients, medical professionals, and society at large.

Media Contact

Corporate Communication Dept., Terumo Corporation

Among the information that Terumo discloses, the forward-looking statements including financial projections are based upon our assumptions using information available to us at the time and are not intended to be guarantees of future events or performance. Accordingly, it should be noted that actual results may differ from those forecasts or projections due to various factors. Factors affecting to actual results include, but are not limited to, changes in economic conditions surrounding Terumo, fluctuations of foreign exchange rates, and state of competition.

Information about products (including products currently in development) included in this material is not intended to constitute an advertisement or medical advice.

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